Nikolas
Created page with "* DNA damage to normal cell -> mutations in genome -> altered gene product -> Tumor suppressors ↓ or oncogenes ↑ * Protective mechanisms against carcinogenesis ** DNA repair enzymes ** Tumor suppressors * Characteristics of cancer cells ** Inhibition of apoptosis + lack of response to inhibitory factors -> capable of self-maintained replication, long survival ** Mutagenic agents/defective DNA repair -> genetic instability -> more mutations ** Capable of angiogenesis..."